Huberman Lab
Huberman Lab

Essentials: Cold & Heat Exposure for Metabolic Health | Dr. Susanna Søberg

November 05, 2026 • 38m

Summary

⏱️ 8 min read

Overview

Dr. Susanna Soberg, a leading researcher in cold thermogenesis, discusses her groundbreaking research on deliberate cold and heat exposure. She reveals optimal protocols for metabolic health, explaining how brown fat activation, insulin sensitivity, and inflammation reduction occur through temperature variation. Her key finding - the 'Soberg Principle' of ending on cold - maximizes metabolic benefits by forcing the body to generate its own heat for hours afterward.

Understanding Cold Shock and Optimal Cold Exposure

Dr. Soberg explains what constitutes effective cold exposure, emphasizing that discomfort is essential for triggering beneficial adaptations. The 'cold shock' response - characterized by hyperventilation and sympathetic nervous system activation - is key to metabolic benefits. However, this response diminishes with adaptation as individuals build resilience, making cold exposure progressively more manageable while maintaining effectiveness.

  • Cold exposure should feel uncomfortable to be effective - you must reach 'uncomfortable cold' to trigger the cold shock response
  • Cold shock activates the sympathetic nervous system and catecholamines, causing hyperventilation and faster breathing
  • Adaptation occurs over time - the hyperventilating response subsides as you build resilience through repeated exposure
  • Cold exposure should be challenging, not comfortable - 'you should do hard things' and 'you should not enjoy it'
" If you enjoy it, then yeah, then I'm thinking something is wrong. It's not right. You should not enjoy it. "

Cold Receptors, Brown Fat, and Metabolic Activation

The mechanism of cold-induced metabolic benefits operates through multiple pathways from skin receptors to brown fat. Cold receptors in the skin send rapid signals to the hypothalamus, which then activates brown fat through noradrenaline release. Remarkably, even minimal cold exposure like putting a hand in cold water or sleeping in a 19-degree Celsius room can activate brown fat and improve insulin sensitivity.

  • Cold receptors send signals to the hypothalamus, the temperature-regulating center in the brain, triggering rapid increases in noradrenaline and adrenaline
  • Brown fat is activated immediately upon cold exposure through direct pathways from skin receptors
  • Different cold exposures activate brown fat differently - full body immersion is most potent, but even cold air or sleeping in cool rooms works
  • Brown fat works together with muscles to maintain body temperature and prevent hypothermia

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