Lex Fridman Podcast
Lex Fridman Podcast

#485 – David Kirtley: Nuclear Fusion, Plasma Physics, and the Future of Energy

November 17, 2025 • 2h 45m

Summary

⏱️ 10 min read

Overview

David Kirtley, CEO of Helion Energy, discusses nuclear fusion technology and its potential to solve humanity's energy needs. The conversation covers the fundamental physics of fusion versus fission, Helion's innovative pulsed magneto-inertial fusion approach using field-reversed configurations (FRCs), and the company's goal to deliver commercial fusion power to Microsoft by 2028. Kirtley emphasizes rapid iteration, manufacturing-focused engineering, and the use of advanced deuterium-helium-3 fuel cycles that enable direct electricity generation at high efficiency.

Nuclear Fusion vs Fission Fundamentals

Kirtley explains the core difference between fusion and fission. Fusion combines lightweight isotopes like hydrogen to create heavier elements, releasing energy from the mass defect described by E=mc². Fission splits heavy unstable elements like uranium. Fusion powers the universe and stars, while fission powers today's nuclear reactors. The key insight is that fusion is fundamentally safe because it requires extreme conditions to maintain, while fission is a self-sustaining chain reaction that can be difficult to control.

  • Fusion combines lightweight hydrogen isotopes together to make heavier elements, releasing energy in the process
  • Fission splits heavy uranium or plutonium atoms apart, also releasing energy
  • The mass defect in both processes converts to energy according to E=mc²
  • Fusion happens up to iron on the periodic table, while heavier elements undergo fission
  • Fusion is fundamentally safe because reactions stop when you stop adding fuel
" Fusion is what powers the universe. Fusion is what happens in stars and it's where the vast amount of energy that even that we use today here on Earth comes from the process of fusion. "
" In fusion, that doesn't happen. And we know because we have to do it every day and it's really hard to do. And so we actually use the word generator because we don't talk about, for instance, a natural gas reactor is that if you stop putting in fuel, it turns off. "

Nuclear Fusion Safety and Proliferation

Kirtley addresses safety concerns around fusion compared to fission reactors. He explains that modern fission reactors are engineered to be safe, but human factors and uranium enrichment processes create proliferation risks. Fusion cannot be used to make nuclear weapons and doesn't require enriched uranium, making it fundamentally safer from both accident and proliferation perspectives. Proliferation experts actively encourage fusion development to avoid the spread of uranium enrichment facilities worldwide.

  • Modern fission reactors are engineered to be safe, but challenges come from humans around the systems
  • Fusion power plants cannot be used to make nuclear weapons unlike fission reactors
  • Hydrogen bombs still require uranium fission reactions - 90% of energy comes from fission
  • Proliferation experts encourage rapid fusion development to avoid worldwide uranium enrichment
" Fusion power plants can't be used to make nuclear weapons. Like fundamentally that the processes in fusion aren't the same processes that happen in nuclear bombs and nuclear weapons. "

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